Saturday, December 22, 2018

Intermittent fasting and Autophagy

For decades, I’ve argued that we all have cancer.  Those of us considered "healthy" are merely (1) not diagnosed, or (2) staying so far ahead of the growth that we never develop symptoms or reach a chronic state.  That is, our bodies are continually operating to eradicate the dysfunctional cells.

The degree to which cancer cells are allowed to persist in our body is a measure of our health, or lack thereof.  Stress, poor diet choices, accumulation of toxins, and lack of effective sleep all contribute to degradation of the immune systems that inhibit accumulation of the cancers in our body.

Now, science is providing the exact descriptions of the mechanisms involved in the clearing process.  We have the opportunity to more fully understand exactly how to support this process.

"Autophagy is the natural, regulated mechanism of the cell that disassembles unnecessary or dysfunctional components."

"The name 'autophagy' was coined by Belgian biochemist Christian de Duve in 1963.  ...first observed by Keith R. Porter and his student Thomas Ashford at the Rockefeller Institute in January 1962."

https://en.m.wikipedia.org/wiki/Autophagy

"Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition"

"Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as reduction of inflammation and induction of cancer cell death."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763238/

"Intermittent fasting— the practice of going without food for some (undefined) period of time — has many health benefits. It can help prevent heart disease, speed fat loss, and slow or reverse aging.
There are a number of physiological mechanisms involved. It reduces inflammation and oxidative stress, leads to increased numbers and quality of mitochondria, and increases autophagy, the cellular self-cleansing process."

"Dr. Naiman suggested that 'the sweet spot for intermittent fasting' occurs between 18 and 24 hours of fasting, since this is the time period that sees the greatest drop in insulin and increase in lipolysis — the breakdown of fat."

"During the fed state, when insulin is increased, the rate of autophagy is low. During the fasted state, as insulin drops, autophagy increases dramatically, perhaps 5-fold."

https://medium.com/the-mission/the-sweet-spot-for-intermittent-fasting-9aae12a2158c

How to Clear Your Body of Senescent Cells Through Activating Autophagy - Dr. Rhonda Patrick
https://youtu.be/K9WGQn44XQo